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158 NETosis is a specific form of programmed cell death in which NADPH oxidase is activated when the concentration of Ca 2+ in the cytoplasm increases, leading to the massive production of ROS and ultimately inducing NETosis

the peak blood levels would hence be substantially lower, by about half

As neurotrophins are vital for neuron survival, synaptic plasticity, and the establishment of neural networks [41,42,43], reduced BDNF and NGF levels caused by folate deficiency can potentially contribute to cognitive deficits and an elevated risk of neurodevelopmental and psychiatric conditions [44, 45]